The Ghost of Mr. Hyde is the villain in the Scooby-Doo, Where Are You! episode "Nowhere to Hyde". He was the disguise of Dr. Jekyll, who used it as a cover for his jewel thefts.
Dr. Jekyll claimed to have made a vitamin formula one would only had to take once in his life, but the concoction went awry and he became the Ghost of Mr. Hyde, a monster transformation also taken on by his great-grandfather. This was a lie, however; Jekyll used the story as a cover for his crimes as the monster, since all his experiments had really failed.
- The Ghost of Mr. Hyde appears in Scooby-Doo! Night of 100 Frights, as pictures in Mystic Manor.
- In Scooby-Doo and the Goblin King, the Ghost of Mr. Hyde is among the real monsters seen in the monster bar.
- A character resembling the Ghost of Mr. Hyde appears on the second page of the Dasien webcomic story "Girl of Goo, Where Are You?".