Scooby-Doo and Scrappy-Doo is the first series in the Scooby-Doo franchise to feature Scooby's nephew, Scrappy-Doo. It was also the last series to feature Fred Jones and Velma Dinkley as regular members of the cast, until the premiere of What's New, Scooby-Doo? 23 years later, in 2002.
- Marla Frumkin as Velma Dinkley
- Casey Kasem as Shaggy Rogers
- Don Messick as Scooby-Doo
- Heather North as Daphne Blake
- Lennie Weinrib as Scrappy-Doo
- Frank Welker as Fred Jones
- The Scarab Lives!
- The Night Ghoul of Wonderworld
- Strange Encounters of a Scooby Kind
- The Neon Phantom of the Roller Disco!
- Shiver and Shake, That Demon's a Snake
- The Scary Sky Skeleton
- The Demon of the Dugout
- The Hairy Scare of the Devil Bear
- Twenty Thousand Screams Under the Sea
- I Left My Neck in San Francisco
- When You Wish Upon a Star Creature
- The Ghoul, the Bat and the Ugly
- Rocky Mountain Yiiii!
- The Sorcerer's a Menace
- Lock the Door, It's a Minotaur
- The Ransom of Scooby Chief
Selected episodes of Scooby-Doo and Scrappy-Doo have been included in the Scooby-Doo: 13 Spooky Tales DVD series. In early February 2015, Warner Archive announced a DVD release of Scooby-Doo and Scrappy-Doo: The Complete Season 1. It was released on April 28.