Scooby-Doo and the gang are trapped in a video game. So they follow Scooby Snacks to the last level and they meet the cyber gang, who just look like them. So, the cyber gang decide to help the gang to defeat the Phantom Virus.
- Joe Alaskey as Officer Wembley
- Bob Bergen as Eric Staufer
- Grey DeLisle as Daphne Blake
- Scott Innes as Scooby-Doo and Shaggy Rogers
- Tom Kane as Professor Robert Kaufman
- Mikey Kelley as Bill McLemore, Eric's rival, who is also the main villain
- Gary Sturgis as the Phantom Virus, the secondary villain
- B. J. Ward as Velma Dinkley
- Frank Welker as Fred Jones
Audio/video unsynchronized: When Scooby and the gang are in the moon level of the game, when Velma says, "Remember what Eric said: We need to find the box of Scooby Snacks," Daphne's voice was heard, but Velma was the one speaking.