Ed Grimley lived alone with his aggressive goldfish, Moby, and his pet rat, Nelson. His hero was Wheel of Fortune host Pat Sajak, he played the triangle, and he had the hots for Miss Malone, an airhead voiced by Catherine O’Hara. Jonathan Winters voiced the short-tempered landlord Leo Freebus, and Short voiced Freebus' wife, the very proper Deidre. Joe Flaherty reprised his SCTV creation Count Floyd, who tried to spook an audience of bored children with his “scaaaary movies”.
- Joe Flaherty as Count Floyd
- Catherine O'Hara as Miss Malone
- Martin Short as Ed Grimley and Deidre Freebus
- Jonathan Winters as Leo Freebus
On January 29, 2013, Warner Home Video released a two-disc "complete series" DVD set of Ed Grimley. The set is available only from Warner Bros.' online store.