Quick Draw McGraw was usually depicted as a sheriff in these short films set in the American Old West. Each episode was approximately six minutes long; this allowed four episodes per half-hour program with commercial advertisements in between. Quick Draw was often accompanied by his deputy, a Mexican burro called Baba Looey, who spoke English with a Mexican accent.
Quick Draw satirized the westerns that were popular among the American public at the time. His character was well-intentioned, but somewhat dim. Often, Baba Looey was a more astute judge of the problem at hand than Quick Draw. Baba Looey would start to tell Quick Draw what he was thinking: "Queeks Draw, I theen...", whereupon Quick Draw would interrupt with his catchphrase: "Now hoooooold on thar, Baba Looey! I'll do the "thinnin'" around here, and doooon't you forget e-it!" Quick Draw spoke with a heavy drawl, as shown by his catchphrase.
Other Quick Draw cartoons featured Snuffles, a treat-loving canine who would help Quick Draw and Baba Looey only after being awarded a dog biscuit. When given the biscuit, Snuffles would moan in joy, hug himself, float up into the air and slowly return to the ground in total ecstasy.
Quick Draw was himself a horse caricature who walked on two legs like a human (as did Baba Looey), and had "hands" that were hooves with thumbs and could hold objects such as guns. This did not stop the show's producers from depicting him riding into town on a realistic horse, or, as seen in the show's opening credits, driving a stagecoach pulled by a whole team of realistic horses. This aspect was spoofed in the 1980s made-for-television film The Good, the Bad and Huckleberry Hound, which featured Quick Draw.
In a series of episodes, Quick Draw would also assume the identity of the masked vigilante "El Kabong" (a parody of Zorro). His introduction went as follows – "Of all the heroes in legend and song, there's none as brave as El Kabong" - As El Kabong, Quick Draw would attack his foes by swooping down on a rope with the onomatopoeia war cry "KABOOOOOONG!", or, at times, "OLAYYYYEEEE!" and hitting them on the head with an acoustic guitar which is always referred to as a "kabonger", producing a distinctive kabong sound and usually destroying the guitar in the process.
Quick Draw McGraw's supporting characters in The Quick Draw McGraw Show were Augie Doggie and Doggie Daddy, father-and-son dogs (the father played as a parody of Jimmy Durante), and Super Snooper and Blabbermouse, cat and mouse detective partners.